Cajun Catfish Supreme is a delightful dish that brings the vibrant and bold flavors of Louisiana cuisine right to your dinner table. This recipe features tender catfish fillets seasoned with a robust blend of Cajun spices, pan-fried to golden perfection, and topped with a creamy, zesty sauce that elevates the dish to supreme status. The appeal of Cajun Catfish Supreme lies in its combination of spice, texture, and the ability to transport you to the bayous of Louisiana with every bite.

Why You Will Love This Recipe
You will love Cajun Catfish Supreme for its explosive flavors and relatively simple preparation. The seasoning blend provides a delightful kick without overwhelming the palate, making it suitable for both spice lovers and those who prefer milder dishes. The creamy sauce adds a rich contrast to the crispy catfish, creating a well-rounded meal that feels indulgent yet can be prepared quickly on a weeknight. Additionally, this recipe fits well into low-carb and high-protein diets, making it a favorite among health-conscious eaters.
Tips and Tricks
- Choose Fresh Catfish: Opt for fresh fillets if possible. Frozen catfish can be convenient but may lack the same flavor and texture.
- Marinate for Extra Flavor: Allow the catfish to marinate in the spice mixture for at least 30 minutes before cooking to enhance the flavors.
- Use a Cast Iron Skillet: For the best sear and crispy texture, a cast iron skillet is ideal, but a non-stick pan will also work.
- Keep it Hot: Ensure your oil is hot enough before adding the catfish to prevent sticking and to achieve that perfect golden-brown crust.
Make Ahead Tips
You can prep the Cajun spice blend a few days in advance and store it in an airtight container. The catfish can also be marinated overnight for a deeper flavor. Cooked catfish can be stored in the refrigerator for up to three days, but the sauce should be made fresh to maintain its creamy texture.

Recipe Variations
- Different Fish: If catfish isn’t available, tilapia or snapper can be excellent substitutes.
- Spice Level: Adjust the heat by adding cayenne pepper for more zing or reducing the amount of paprika for a milder dish.
- Alternate Cooking Methods: For a healthier option, consider baking the catfish at 400°F for 12-15 minutes or air-frying for a crispy finish without the oil.
How to Serve
Serve your Cajun Catfish Supreme on a bed of fluffy white rice or creamy grits to soak up the delicious sauce. Garnish with freshly chopped parsley or green onions for a pop of color. Place lemon wedges on the side for a zesty squeeze that brightens the dish.

Pairing Suggestions
Pair this dish with a crisp Sauvignon Blanc or a refreshing iced tea. For a heartier meal, consider serving it alongside classic Southern sides like coleslaw, cornbread, or sautéed greens. For dessert, a slice of pecan pie would perfectly round out your Cajun-inspired feast.
How to Store
Store any leftover Cajun Catfish Supreme in an airtight container in the refrigerator for up to three days. For longer storage, consider freezing the cooked catfish without the sauce; it can last up to a month. To reheat, thaw in the refrigerator overnight and warm in a skillet over medium heat until heated through.
Equipment Needed
- Cast Iron Skillet: Ideal for frying the catfish and achieving a crispy crust.
- Mixing Bowls: For combining your spices and marinating the fish.
- Tongs: To flip the fish without breaking it.
- Measuring Spoons: To ensure proper spice measurements.

Dietary Adaptations
- Gluten-Free: Ensure your Cajun spice mix is gluten-free, and serve with rice instead of bread.
- Dairy-Free: Substitute the cream in the sauce with coconut milk or a dairy-free cream alternative.
- Nut-Free: This recipe is naturally nut-free but always check your spice blends for cross-contamination.
Seasonal Adaptations
In the summer, fresh peppers and herbs can be added to the sauce for a burst of flavor. During winter, consider using smoked paprika to impart a warm, smoky flavor to the dish, reminiscent of cozy evenings.
Recipe FAQs
- Can I use frozen catfish? Yes, but make sure to thaw it completely before marinating and cooking.
- How long does it take to cook catfish? Typically, it takes 4-5 minutes per side, depending on the thickness of the fillet.
- Can I make this dish in advance? While the catfish is best enjoyed fresh, you can marinate it ahead of time and prepare the sauce in advance.
How To Make Cajun Catfish Supreme
Cajun Catfish Supreme

Cajun Catfish Supreme is a delightful dish that brings the vibrant and bold flavors of Louisiana cuisine right to your dinner table.
Ingredients
- 4 catfish fillets
- 2 tablespoons Cajun seasoning
- 1 cup buttermilk
- 1 cup all-purpose flour
- 1/2 cup cornmeal
- 1/4 cup mayonnaise
- 1 tablespoon Dijon mustard
- 1 tablespoon lemon juice
- 2 tablespoons chopped fresh parsley
- Salt and pepper to taste
- Vegetable oil for frying
Instructions
- Marinate the Catfish: In a mixing bowl, combine buttermilk and Cajun seasoning. Add catfish fillets and let marinate in the refrigerator for at least 30 minutes.
- Prepare the Coating: In another bowl, mix flour, cornmeal, salt, and pepper. Remove catfish from the marinade and shake off excess.
- Coat the Catfish: Dredge each fillet in the flour mixture, pressing lightly to adhere.
- Heat the Oil: In a cast iron skillet, heat about 1/2 inch of vegetable oil over medium-high heat until shimmering.
- Fry the Catfish: Carefully add the fillets to the hot oil. Fry for 4-5 minutes on each side until golden brown and cooked through. Remove and drain on paper towels.
- Make the Sauce: In a small bowl, whisk together mayonnaise, Dijon mustard, lemon juice, and parsley until smooth.
- Serve: Plate the fried catfish and drizzle the creamy sauce over the top. Garnish with additional parsley and lemon wedges.
Nutrition Information
Yield
4Serving Size
1Amount Per Serving Calories 532Total Fat 26gSaturated Fat 5gTrans Fat 0gUnsaturated Fat 19gCholesterol 103mgSodium 2183mgCarbohydrates 40gFiber 3gSugar 3gProtein 33g
Easy Shrimp Recipes.com, occasionally offers nutritional information for recipes contained on this site. This information is provided as a courtesy and is an estimate only. This information comes from online calculators. Although allchickenrecipes.com attempts to provide accurate nutritional information, these figures are only estimates.
Final Thoughts
Cajun Catfish Supreme is not just a meal; it’s an experience that encapsulates the spirit of Louisiana cooking. With its bold flavors, creamy sauce, and crispy texture, this dish is sure to impress family and friends alike. Whether you’re a seasoned cook or a beginner, this recipe provides an opportunity to explore the vibrant world of Cajun cuisine. So, roll up your sleeves, gather your ingredients, and let the cooking adventure begin!